The Silcoff Selections: NFL Week 6 Predictions – Straight Up & Against the Spread Picks

The Silcoff Selections are here for Week 6 of the 2025 NFL Season! Below are my records for my straight up and against the spread picks for the season thus far.

Records Last Week:

Straight Up: 7-7

Against The Spread: 6-8

Season Records:

Straight Up: 46-31-1

Against The Spread: 32-45-1

Thursday Night Football: Philadelphia Eagles (4-1) @ New York Giants (1-4) I Line: Eagles -7

The Eagles enter Week 6 angry and motivated after suffering their first loss of the year. Facing a Giants team that lacks offensive firepower without Malik Nabers, Philadelphia should handle business on the road. Expect an Eagles win to help the defending champions get back on track.

Score Prediction: Eagles 26, Giants 17

ATS Pick: Eagles -7

Early Sunday Slate: Bronocs-Jets Battle In London

Denver Broncos (3-2) vs New York Jets (0-5) I Line: Broncos -7

The Jets remain the NFL’s only winless team heading into London, while Denver is coming off a massive road win in Philadelphia. With momentum finally on their side, the Broncos should take care of business overseas and pick up another victory with ease.

Score Prediction: Broncos 30, Jets 18

ATS Pick: Broncos -7

Arizona Cardinals (2-3) @ Indianapolis Colts (4-1) I Line: Colts -7

Shockingly, the Colts sit atop the AFC as the No. 1 seed five weeks into the season, while the Cardinals limp into Week 6 after three straight losses. Arizona will play desperate, and Marvin Harrison Jr. — returning to Indianapolis for the first time — should have a big day, possibly finding the end zone. Still, the Colts’ strong coaching and consistency should prevail in a close home win.

Score Prediction: Colts 28, Cardinals 22

ATS Pick: Cardinals +7

Cleveland Browns (1-4) @ Pittsburgh Steelers (3-1) I Line: Steelers -5.5

The Steelers come in rested off their bye and should control the tempo against a Browns team returning from overseas travel. Expect a physical, low-scoring affair — but the Steelers take care of business at home.

Score Prediction: Steelers 22, Browns 15

ATS Pick: Steelers -5.5

Dallas Cowboys (2-2-1) @ Carolina Panthers (2-3) I Line: Cowboys -3

Dak Prescott has officially entered the MVP conversation. With the Cowboys offense firing on all cylinders, Dallas should cruise past Carolina much like they did against the Jets last week. Expect another efficient performance from Prescott and a comfortable Cowboys victory.

Score Prediction: Cowboys 31, Panthers 21

ATS Pick: Cowboys -3

Los Angeles Chargers (3-2) @ Miami Dolphins (1-4) I Line: Chargers -4

The Chargers continue to battle injuries along the offensive line and running back room, meaning this will fall squarely on Justin Herbert’s shoulders. Fortunately, Miami’s defense has been underwhelming, giving Herbert the perfect chance to carve them up. The Chargers win on the road.

Score Prediction: Chargers 24, Dolphins 19

ATS Pick: Chargers -4

Los Angeles Rams (3-2) @ Baltimore Ravens (1-4) I Line: Rams -7.5

With Lamar Jackson expected to sit out another week before the Ravens’ upcoming bye, the Rams have an opportunity to bounce back after last Thursday’s humiliation. Expect Los Angeles to respond in a big way and pick up a much-needed road victory to stay in the NFC West race.

Score Prediction: Rams 28, Ravens 17

ATS Pick: Rams -7.5

New England Patriots (3-2) @ New Orleans Saints (1-4) I Line: Patriots -3.5

New England shocked the league last week by upsetting the Bills, highlighted by what felt like Drake Maye’s breakout performance. The Saints, meanwhile, finally picked up their first win of the season. This could be a trap game for the Patriots, but New England should edge out the Saints on the road.

Score Prediction: Patriots 26, Saints 20

ATS Pick: Patriots -3.5

Seattle Seahawks (3-2) @ Jacksonville Jaguars (4-1) I Line: Jaguars -1

The Jaguars are riding high after a huge Monday Night Football win over the Chiefs, while Seattle is looking to rebound from a thriller against the Buccaneers. Expect the Seahawks defense to force a few turnovers from Trevor Lawrence, with Sam Darnold finding Jaxon Smith-Njigba early and often. Seattle gets a gritty win on the road.

Score Prediction: Seahawks 24, Jaguars 23

ATS Pick: Seahawks +1

Sunday Afternoon Slate: 49ers-Bucs Play In Huge NFC Clash

San Francisco 49ers (4-1) @ Tampa Bay Buccaneers (4-1) I Line: Buccaneers -3

Both the 49ers and Buccaneers are legitimate Super Bowl contenders when healthy, but both enter Week 6 banged up. The edge goes to San Francisco, who will have extra time to prepare after playing last Thursday. Tampa Bay, fresh off an emotional win in Seattle, could face a letdown. The 49ers win a hard-fought one on the road.

Score Prediction: 49ers 26, Buccaneers 24

ATS Pick: 49ers +3

Tennessee Titans (1-4) @ Las Vegas Raiders (1-4) I Line: Raiders -4.5

Let me say for the record, I WILL NOT BE WATCHING THIS GAME. Tennessee finally notched their first win last week of the Cam Ward era, but I like the Raiders here at home. If Geno Smith can protect the ball and avoid costly turnovers, Las Vegas should be able to win comfortably and move to 2-4.

Score Prediction: Raiders 24, Titans 17

ATS Pick: Raiders -4.5

Cincinnati Bengals (2-3) @ Green Bay Packers (3-1-1) I Line: Packers -14

The Packers return from their bye refreshed, while the Bengals turn to veteran Joe Flacco following a midweek trade. Without Joe Burrow, Cincinnati will struggle to keep up offensively. Green Bay wins convincingly at home.

Score Prediction: Packers 30, Bengals 17

ATS Pick: Bengals +14

Sunday Night Football: Detroit Lions (4-1) @ Kansas City Chiefs (2-3) I Line: Chiefs -2.5

The Lions are playing elite football since their Week 1 loss, while Kansas City has been strangely inconsistent. In what could be a statement win, Detroit goes into Arrowhead and comes away with another W.

Score Prediction: Lions 27, Chiefs 24

ATS Pick: Lions +2.5

Monday Night Football Game #1: Buffalo Bills (4-1) @ Atlanta Falcons (2-2) I Line: Bills -4.5

After last week’s disappointing loss, expect Buffalo to come out angry. Josh Allen thrives indoors, and the Falcons have a habit of folding against superior teams. Bills roll in Atlanta.

Score Prediction: Bills 28, Falcons 21

ATS Pick: Bills -4.5

Monday Night Football Game #2: Chicago Bears (2-2) @ Washington Commanders (3-2) I Line: Commanders -4.5

In a rematch of last season’s heartbreaking Hail Mary finish, I think Jayden Daniels and the Commanders take down the Bears once again. Chicago, fresh off a bye, should look sharp, and I expect Caleb Williams and Ben Johnson to put together a solid game plan early; however, Daniels and the Commanders get things going in the second half against this shaky Chicago defense to pick up a home W.

Score Prediction: Commanders 28, Bears 23

ATS Pick: Commanders -4.5

Straight Up/Moneyline Picks:

• Eagles

• Broncos

• Colts

• Steelers

• Cowboys

• Chargers

• Rams

• Patriots

• Seahawks

• Raiders

• Packers

• 49ers

• Lions

• Bills

• Commanders

Picks ATS:

• Eagles -7

• Broncos -7

• Cardinals +7

• Steelers -5.5

• Cowboys -3

• Chargers -4

• Rams -7.5

• Patriots -3.5

• Seahawks +1

• Raiders -4.5

• Bengals +14

• 49ers +3

• Lions +2.5

• Bills -4.5

• Commanders -4.5