The Silcoff Selections: NFL Week 10 Predictions – Straight Up & Against the Spread Picks

The Silcoff Selections are here for Week 10 of the 2025 NFL Season! Below are my records for my straight up and against the spread picks for the season thus far.

Records Last Week:

Straight Up: 9-5

Against The Spread: 5-9

Season Records:

Straight Up: 83-51-1

Against The Spread: 61-73-1

Thursday Night Football: Las Vegas Raiders (2-6) @ Denver Broncos (7-2) I Line: Broncos -9

The Broncos have quietly reeled off six straight wins — and while many of those victories have been far from pretty, winning is winning. They’re back home in primetime, and I like Denver convincingly in this one.

I expect Geno Smith to struggle, likely turning the ball over multiple times. Running back RJ Harvey should find the end zone at least once, possibly twice. The Raiders’ direction under Pete Carroll becomes a serious talking point after this one. Denver rolls.

Score Prediction: Broncos 28, Raiders 17

ATS Pick: Broncos -9

Early Sunday Slate: Colts-Falcons Fly Over to Berlin

Berlin Game: Atlanta Falcons (3-5) vs Indianapolis Colts (7-2) I Line: Colts -6.5

The Colts made headlines this week with their blockbuster trade for Sauce Gardner. Whether Sauce suits up or not, I’m still rolling with Indianapolis. The Falcons remain too inconsistent to rely on, and the Colts will be motivated to bounce back after a tough loss in Pittsburgh.

Score Prediction: Colts 26, Falcons 22

ATS Pick: Falcons +6.5

Baltimore Ravens (3-5) @ Minnesota Vikings (4-4) I Line: Ravens -4

Both teams are in must-win territory. The Vikings surprised Detroit last week with J.J. McCarthy returning, but Baltimore had 10 days to prepare and Lamar Jackson historically dominates NFC opponents. I like the Ravens on the road.

Score Prediction: Ravens 28, Vikings 23

ATS Pick: Ravens -4

Buffalo Bills (6-2) @ Miami Dolphins (2-7) I Line: Bills -9.5

The Dolphins checked out months ago. Meanwhile, Buffalo — coming off a massive emotional win over Kansas City — remains focused on chasing the AFC’s #1 seed. Bills take of business on the road.

Score Prediction: Bills 31, Dolphins 20

ATS Pick: Bills -9.5

New Orleans Saints (1-8) @ Carolina Panthers (5-4) I Line: Panthers -5.5

Carolina is coming off the upset of the season, defeating the Packers at Lambeau. Bryce Young wasn’t perfect, but he managed the game well and should carry that momentum forward.

The Saints dealt Rahid Shaheed to Seattle and look to be shifting toward a reset. Rookie QB Tyler Shough was underwhelming in his debut. Behind a strong rushing effort from Rico Dowdle and Chuba Hubbard, I like the Panthers to win comfortably and move to 6–4.

Score Prediction: Panthers 24, Saints 14

ATS Pick: Panthers -5.5

Cleveland Browns (2-6) @ New York Jets (1-7) I Line: Browns -2

The Jets have officially committed to the tank, dealing both Quinnen Williams and Sauce Gardner. Cleveland’s defense is easily the best unit on the field, and with Myles Garrett fresh off a bye, I expect him to dominate.

Score Prediction: Browns 17, Jets 14

ATS Pick: Browns -2

New York Giants (2-6) @ Chicago Bears (5-3) I Line: Bears -4.5

I’m calling the upset here.

Caleb Williams showed growth last week, but the Giants’ defense should be able to pressure him consistently, Jaxson Dart has gotten better each week for New York. The Bears are coming off an emotional, chaotic win over Cincinnati — a classic letdown spot.

Score Prediction: Giants 24, Bears 23

ATS Pick: Giants +4.5

Jacksonville Jaguars (5-3) @ Houston Texans (3-5) I Line: Jaguars -1.5

C.J. Stroud has already been ruled out with a concussion, but the Texans are only underdogs which should tell you a lot about Jacksonville. Davis Mills isn’t new to starting; he’s capable and already showed chemistry with Nico Collins last week.

Houston is the more desperate team with slim playoff hopes on the line. At home, with urgency, I like the Texans.

Score Prediction: Texans 21, Jaguars 19

ATS Pick: Texans +1.5

New England Patriots (7-2) @ Tampa Bay Buccaneers (6-2) I Line: Buccaneers -2.5

Both teams sit with only two losses and are legitimate contenders. Injuries are a factor on both sides, including uncertainty around Bucky Irving, Chris Godwin, Kayshon Boutte, and Rhamondre Stevenson.

Tampa Bay is coming off a bye, while New England has won six straight and is due for a stumble. In a tight, entertaining matchup, I’ll take the more-rested team at home in a very entertaining game.

Score Prediction: Buccaneers 24, Patriots 21

ATS Pick: Buccaneers -2.5

Afternoon Slate: JSN, Seahawks Look to Keep Momentum Going

Arizona Cardinals (3-5) @ Seattle Seahawks (6-2) I Line: Seahawks -6.5

Jacoby Brissett has been named Arizona’s QB moving forward — even over a healthy Kyler Murray. The Cardinals shocked Dallas on Monday night, and this has all the makings of a trap game for Seattle.

The Cardinals always seem to play the Seahawks tough in Seattle, but I still think the Seahawks pull it out — just in a closer game than expected.

Score Prediction: Seahawks 26, Cardinals 21

ATS Pick: Cardinals +6.5

Detroit Lions (5-3) @ Washington Commanders (3-6) I Line: Lions -8

Without Jayden Daniels, Washington simply doesn’t have the firepower to hang. The Lions are coming off an ugly loss to Minnesota and will be fired up — especially with playoff revenge on their minds.

Score Prediction: Lions 34, Commanders 20

ATS Pick: Lions -8

Los Angeles Rams (6-2) @ San Francisco 49ers (6-3) I Line: Rams -5.5

This matchup is critical for both teams' NFC West hopes. The Rams didn’t lose the first meeting, and I can’t see them getting swept by a 49ers team led by Mac Jones. Matthew Stafford has been excellent, and Puka Nacua and Davante Adams are heating up fast.

The Rams are simply the healthier, more complete team right now.

Score Prediction: Rams 28, 49ers 24

ATS Pick: 49ers +5.5

Sunday Night Football: Pittsburgh Steelers (5-3) @ Los Angeles Chargers (6-3) I Line: Chargers -3

The Chargers narrowly escaped Tennessee but lost star tackle Joe Alt for the season. Trevor Penning is not an equal replacement. With a heavy Steelers fan presence in Los Angeles and Aaron Rodgers returning to his home state, I see Pittsburgh pulling off a road win. Expect T.J. Watt to be the difference-maker.

Score Prediction: Steelers 23, Chargers 20

ATS Pick: Steelers +3

Monday Night Football: Philadelphia Eagles (6-2) @ Green Bay Packers (5-2-1) I Line: Packers -2.5

Green Bay is banged up and inconsistent, losing Tucker Kraft — arguably their best receiving option this season. Philadelphia is coming off a bye and should be fresh, focused, and ready to clean up execution issues.

Expect Saquon Barkley to have a strong game and A.J. Brown to be more involved.

Score Prediction: Eagles 27, Packers 24

ATS Pick: Eagles +2.5

Straight Up/Moneyline Picks:

• Broncos

• Colts

• Ravens

• Bills

• Panthers

• Browns

• Giants

• Texans

• Buccaneers

• Seahawks

• Lions

• Rams

• Steelers

• Eagles

Picks ATS:

• Broncos -9

• Falcons +6.5

• Ravens -4

• Bills -9.5

• Panthers -5.5

• Browns -2

• Giants +4.5

• Texans +1.5

• Buccaneers -2.5

• Cardinals +6.5

• Lions -8

• 49ers +5.5

• Steelers +3

• Eagles +2.5