The Silcoff Selections: NFL Week 4 Predictions – Straight Up & Against the Spread Picks

The Silcoff Selections are here for Week 4 of the 2025 NFL Season! Below are my records for my straight up and against the spread picks for the season thus far.

Records Last Week:

Straight Up: 7-9

Against The Spread: 4-12

Season Records:

Straight Up: 27-21

Against The Spread: 16-32

Thursday Night Football: Seattle Seahawks (2-1) @ Arizona Cardinals (2-1) I Line: Seahawks -1.5

The Seahawks have historically owned Arizona, and Kyler Murray hasn’t beaten Seattle since 2020. The Seahawks’ elite defense should be too much for the sputtering Cardinals’ offense.

Score Prediction: Seahawks 24, Cardinals 17

ATS Pick: Seahawks -1.5

Early Sunday Slate: Vikings-Steelers Battle in Dublin

Pittsburgh Steelers (2-1) vs Minnesota Vikings (2-1) I Line: Vikings -2.5

The first international game of the year brings Pittsburgh and Minnesota to Dublin. I think the Vikings’ pass rush overwhelms Aaron Rodgers, forcing turnovers. Carson Wentz and the offense do just enough.

Score Prediction: Vikings 27, Steelers 20

ATS Pick: Vikings -2.5

Carolina Panthers (1-2) @ New England Patriots (1-2) I Line: Patriots -5.5

I like New England to get a comfortable win here. The defense harasses Bryce Young all day, and Drake Maye takes advantage of Carolina’s shaky defense.

Score Prediction: Patriots 27, Panthers 16

ATS Pick: Patriots -5.5

Cleveland Browns (1-2) @ Detroit Lions (2-1) I Line: Lions -10

the Browns pulled off the upset of the season last weekend beating the Packers as Myles Garrett and Mason Graham have been incredible for Cleveland's defense, but their offense won’t keep pace with Detroit. After a big win in Baltimore, Jared Goff and the Lions roll at home.

Score Prediction: Lions 30, Browns 16

ATS Pick: Lions -10

Los Angeles Chargers (3-0) @ New York Giants (0-3) I Line: Chargers -6.5

Jaxson Dart makes his first start for the Giants which should give this New York some juice, but Justin Herbert is on another level right now. With Quentin Johnston, Keenan Allen, and Ladd McConkey rolling, the Chargers move to 4-0.

Score Prediction: Chargers 24, Giants 17

ATS Pick: Chargers -6.5

New Orleans Saints (0-3) @ Buffalo Bills (3-0) I Line: Bills -15.5

Not much to say here, the Saints may be the worst team in football, and the Bills might be the best. I don't even think Josh Allen will play four quarters in this one.

Score Prediction: Bills 35, Saints 20

ATS Pick: Saints +15.5

Philadelphia Eagles (3-0) @ Tampa Bay Buccaneers (3-0) I Line: Eagles -3.5

Tampa Bay has played Philly tough in the past, but without Mike Evans and with a banged-up offensive line, it’s too much to ask. Baker keeps the Bucs fighting but the Eagles stay unbeaten.

Score Prediction: Eagles 23, Buccaneers 20

ATS Pick: Buccaneers +3.5

Tennessee Titans (0-3) @ Houston Texans (0-3) I Line: Texans -7

A battle of 0-3 AFC South teams. I’ll take the best unit on the field — Houston’s defense. C.J. Stroud connects with Nico Collins late, and the Texans hold Tennessee under 14 points.

Score Prediction: Texans 20, Titans 12

ATS Pick: Texans -7

Washington Commanders (2-1) @ Atlanta Falcons (1-2) I Line: Commanders -1

Washington might be without Jayden Daniels and Terry McLaurin, and if they are, that’s too much to overcome. Michael Penix should bounce back from a tough Week 3, and Atlanta gets a huge win at home.

Score Prediction: Falcons 23, Commanders 20

ATS Pick: Falcons +1

Sunday Afternoon Slate: Chiefs-Ravens Each Try to Avoid a 1-3 Start

Baltimore Ravens (1-2) @ Kansas City Chiefs (1-2) I Line: Ravens -2.5

Game of the week. Lamar Jackson just simply does not play well against Patrick Mahomes, and until he does, I can’t pick Baltimore in this matchup. The Chiefs get their first home win of 2025.

Score Prediction: Chiefs 28, Ravens 24

ATS Pick: Chiefs +2.5

Indianapolis Colts (3-0) @ Los Angeles Rams (2-1) I Line: Rams -3.5

Daniel Jones thus far has revived his career in Indy, but I don’t love this matchup for the Colts. Matthew Stafford and Sean McVay bounce back from last week’s loss and torch the Colts’ secondary.

Score Prediction: Rams 27, Colts 20

ATS Pick: Rams -3.5

Jacksonville Jaguars (2-1) @ San Francisco 49ers (3-0) I Line: 49ers -3

Despite the injuries, the 49ers are 3-0 and might get Brock Purdy back. Even if they don’t, I trust their coaching staff and defense to get after Trevor Lawrence even without Nick Bosa.

Score Prediction: 49ers 23, Jaguars 17

ATS Pick: 49ers -3

Chicago Bears (1-2) @ Las Vegas Raiders (1-2) I Line: Raiders -1.5

Caleb Williams had his best game as a pro last week, and Las Vegas is coming off a humiliating loss in Washington. With Geno Smith looking average in Vegas, I’ll take the Bears to ride the momentum.

Score Prediction: Bears 27, Raiders 24

ATS Pick: Bears +1.5

Sunday Night Football: Green Bay Packers (2-1) @ Dallas Cowboys (1-2) I Line: Packers -6.5

Micah Parsons makes his Dallas return, but without CeeDee Lamb, I can’t see the Cowboys keeping up. Jordan Love takes advantage of Dallas’ weak defense, and Green Bay wins big on the road.

Score Prediction: Packers 31, Cowboys 20

ATS Pick: Packers -6.5

Monday Night Football Doubleheader

New York Jets (0-3) @ Miami Dolphins (0-3) I Line: Dolphins -3

Miami is deeper, healthier, and has extra rest. Dolphins get their first win of the year and the Jets fall to 0-4.

Score Prediction: Dolphins 26, Jets 21

ATS Pick: Dolphins -3

Cincinnati Bengals (2-1) @ Denver Broncos (1-2) I Line: Broncos -7.5

Denver’s defense rattles Jake Browning, and Bo Nix does just enough to get the Broncos to .500.

Score Prediction: Broncos 26, Bengals 19

ATS Pick: Bengals +7.5

Straight Up/Moneyline Picks:

• Seahawks

• Vikings

• Patriots

• Lions

• Chargers

• Bills

• Eagles

• Texans

• Falcons

• Chiefs

• Rams

• 49ers

• Bears

• Packers

• Dolphins

• Broncos

Picks ATS:

• Seahawks -1.5

• Vikings -2.5

• Patriots -5.5

• Lions -10

• Chargers -6.5

• Saints +15.5

• Buccaneers +3.5

• Texans -7

• Falcons +1

• Chiefs +2.5

• Rams -3.5

• 49ers -3

• Bears +1.5

• Packers -6.5

• Dolphins -3

• Bengals +7.5