The Silcoff Selections: NFL Week 10 Predictions – Straight Up & Against the Spread Picks

The Silcoff Selections are here for Week 10 of the 2026 NFL Season! Below are my records for my straight up and against the spread picks for the season thus far.

Records Last Week:

Straight Up: 15-0

Against The Spread: 11-4

Season Records:

Straight Up: 87-48-1

Against The Spread: 69-66-1

Thursday Night Football: Washington Commanders (2-5-1) @ New York Giants (5-2-1) I Line: Giants -2.5

The rematch from the famous tie earlier in the season. I don't think the Giants are 6-2-1 good. Sometimes you just gotta look at the records. Call me crazy, but give me the Commanders on the road with the better quarterback.

Score Prediction: Commanders 23, Giants 21

ATS Pick: Commanders +2.5

Sunday Slate:

New England Patriots (5-4) vs Detroit Lions (6-2) I Line: Lions -2.5

I love the Lions this week as they take on the Patriots in Germany. New England is coming in banged up on offense, while Detroit’s offense is always humming and the defense is starting to get going. Give me Detroit to get the win.

Score Prediction: Lions 26, Patriots 21

ATS Pick: Lions -2.5

Buffalo Bills (7-1) @ New York Jets (2-6) I Line: Bills -7.5

After a physical game on Monday night in Minnesota, I like Buffalo’s offense to get back on track. Bills win a divisional road matchup in New York.

Score Prediction: Bills 31, Jets 20

ATS Pick: Bills -7.5

Carolina Panthers (3-5) @ New Orleans Saints (3-5) I Line: Saints -2.5

The Saints have struggled at home this year, picking up their first win in the Superdome just last week against Cleveland, while the Panthers have lost three straight. It feels like whenever Carolina is backed against the wall, that’s when Bryce Young pulls you back in. Give me the Panthers to go on the road and win a big NFC South game.

Score Prediction: Panthers 24, Saints 23

ATS Pick: Panthers +2.5

Houston Texans (3-5) @ Cleveland Browns (5-4) I Line: Texans -4.5

Does a Deshaun Watson "revenge" game interest anyone in 2026? Watson is back after missing last week for the Browns, but unfortunately, I think it will result in another loss. C.J. Stroud and this Texans offense are on fire right now, and if their defense can catch up, the Texans could potentially make a run to the playoffs. I think this is a good matchup for them. Give me Houston to win.

Score Prediction: Texans 24, Browns 16

ATS Pick: Texans -4.5

Jacksonville Jaguars (6-2) @ Tennessee Titans (1-7) I Line: Jaguars -10.5

This might be the best team in football going up against the worst team in football. Jacksonville wins easy.

Score Prediction: Jaguars 30, Titans 17

ATS Pick: Jaguars -10.5

Kansas City Chiefs (6-2) @ Atlanta Falcons (3-6) I Line: Chiefs -3.5

It would be the most Falcons thing ever to lose three of their last four games, only to have those two wins come against potentially the two Super Bowl teams in the 49ers and Chiefs. I don't know why, but I just like Atlanta at home in this spot.

Patrick Mahomes is dealing with an elbow injury, and I still have questions about the Chiefs' defense despite what they showed last week against the Jets. The Falcons' offensive line is solid, and as long as they give Michael Penix Jr. time in the pocket, he'll get the ball to his playmakers. Give me the Falcons to pull off the home upset.

Score Prediction: Falcons 24, Chiefs 21

ATS Pick: Falcons +3.5

Miami Dolphins (1-7) @ Indianapolis Colts (2-7) I Line: Colts -3.5

Why couldn't this be the European game? Just give me the home team with the better players. The Colts finally get a win.

Score Prediction: Colts 23, Dolphins 14

ATS Pick: Colts -3.5

Minnesota Vikings (6-2) @ Green Bay Packers (6-3) I Line: Packers -3.5

I was all but ready to write off the Vikings after their performance on Monday night, but then they made a trade for Kirk Cousins. While I still don't think this solidifies them as true Super Bowl contenders, because we saw a similar story when he signed with them in 2018, there's no doubt it makes them better right now.

Green Bay and Jordan Love are playing some great football right now, and they're getting healthier. Depending on how good Micah Parsons is, I do think they could very well be the team that comes out of the NFC and makes the Super Bowl. They're a true contender.

But in this spot, I don't know why, I just really like the Vikings this weekend. Green Bay's offensive line still isn't great, and I think with a new quarterback, assuming Kirk Cousins is playing this week, I could see this Minnesota team coming out with their hair on fire. The whole team now feels like they have a true chance to do something special.

Give me the Vikings to go into Lambeau and end their two-game losing streak.

Score Prediction: Vikings 22, Packers 21

ATS Pick: Vikings +3.5

Los Angeles Rams (5-4) @ Arizona Cardinals (3-6) I Line: Rams -9.5

Even without Puka Nacua and Davante Adams, this is Matthew Stafford and Sean McVay in a must-win spot. Not to mention, for the Cardinals, it's Carson Beck making his first career start against a defense featuring Myles Garrett and Aaron Donald. Call me crazy, but I can smell the IR stint.

Score Prediction: Rams 26, Cardinals 14

ATS Pick: Rams -9.5

Seattle Seahawks (5-4) @ Las Vegas Raiders (4-5) I Line: Seahawks -6.5

The Seahawks' defence is going up against Fernando Mendoza in his first career start, and assuming it's Drew Lock under centre for Seattle, I like the Seahawks to take care of business on the road. Mike Macdonald is going to make Mendoza's first career start absolutely hellacious.

Score Prediction: Seahawks 20, Raiders 13

ATS Pick: Seahawks -6.5

San Francisco 49ers (7-1) @ Dallas Cowboys (4-5) I Line: 49ers -4.5

This might be a sucker's line, but I think the Cowboys are awful, while the 49ers are playing like the best team in the NFC right now and very well might be playing for a Lombardi Trophy in February. San Francisco takes care of business on the road, and this offense puts up numbers against the Cowboys' defense.

Score Prediction: 49ers 34, Cowboys 24

ATS Pick: 49ers -4.5

Sunday Night Football: Pittsburgh Steelers (6-2) @ Cincinnati Bengals (6-2) I Line: Bengals -3.5

The Steelers beat the Bengals earlier in the season, but the way Cincinnati's offense is rolling right now, it's tough to pick against them. I think this could very well be Joe Burrow's MVP statement game under the bright lights. Bengals win at home in primetime.

Score Prediction: Bengals 27, Steelers 23

ATS Pick: Bengals -3.5

Monday Night Football: Los Angeles Chargers (0-8) @ Baltimore Ravens (4-5) I Line: Ravens -4.5

I can't believe I'm saying this, but I think Jacoby Brissett is going to give the Baltimore Ravens so much life. He's actually able to throw the ball downfield. The Chargers suck, and they won't be able to take away Derrick Henry. Based on how this Chargers season has gone, you just can't pick them in any game. I can't believe this is a Monday Night Football matchup, but nevertheless, I think the Ravens take care of business at home and get themselves back into the AFC playoff picture, at the very least, while the Chargers will once again be looking for their first win.

Score Prediction: Ravens 21, Chargers 13

ATS Pick: Ravens -4.5

Straight Up/Moneyline Picks:

• Commanders

• Lions

• Bills

• Panthers

• Texans

• Jaguars

• Falcons

• Colts

• Vikings

• Rams

• Seahawks

• 49ers

• Bengals

• Ravens

Picks ATS:

• Commanders +2.5

• Lions -2.5

• Bills -7.5

• Panthers +2.5

• Texans -4.5

• Jaguars -10.5

• Falcons +3.5

• Colts -3.5

• Vikings +3.5

• Rams -9.5

• Seahawks -6.5

• 49ers -4.5

• Bengals -3.5

• Ravens -4.5